Table of Contents
What are the examples of suspending agent?
The most common suspending agents are aqueous biological polymers, including methylcellulose (MC), sodium carboxymethylcellulose (CMC), and hydroxypropylmethylcellulose (HPMC).
What are suspending agents how they works?
A suspending agent is a liquid in which a solid substance can be held in suspension. The drug is held in the suspension by a suspending agent, and does not settle at the bottom. If the tablet is dissolved in a suspending agent, this will help suspend any insoluble components in the liquid.
Which suspending agent is used in the formulation of suspension?
Xanthan gum in drug delivery applications XG is widely used as a suspending agent and stabilizer in suspension due to its safety properties in food and drug applications.
Which is the best suspending agent?
Methyl cellulose and hydroxypropylmethylcellulose were both considered to be equally satisfactory as the agent of first choice. Gum tragacanth performed slightly less well with the cationic drug used than the cellulose based agents.
What is the purpose in adding suspending agents in suspensions?
Suspending or thickening agents are added to suspensions to thicken the suspending medium, thereby reducing the movement (sedimentation) of suspended particles and physically stabilizing the product.
Which can be used as emulsifying and suspending agent?
Some examples of the inorganic salts that we can use as suspending agents include clay, bentonite, and aluminum hydroxide. Synthetic compounds are also made as suspending agents in order to overcome the various problems occurring from natural products. e.g. carbomers and colloidal silicon dioxide.
What are the advantages of suspension?
Advantages of a Suspension:
- A suspension is a dosage form that can improve the chemical stability of certain drugs.
- Suspension can improve the taste of various unpleasant/bitter tastes of the drug by masking them.
- The drug in suspension exhibits a higher rate of bioavailability than other dosage forms.
What are the advantages of tragacanth as suspending agent?
Tragacanth provides thixotrophy to a solution (forms pseudoplastic solutions). The maximum viscosity of the solution is achieved after several days, due to the time taken to hydrate completely. Tragacanth is stable at a pH range of 4-8. It is a better thickening agent than acacia.
Is clay used as suspending agent?
Clays such as attapulgite and Western bentonite are used as suspending agents (Salladay et aI., 1984).
How does a suspending agents increases the viscosity of the liquid?
By reducing particle size, by increasing the viscosity, and by increasing the density of the external phase, we may retard settling. Suspending agents are physiologically inert substances which increase viscosity when added to suspensions.
Why suspension is used over the solution?
A suspension is a heterogeneous mixture in which some of the particles settle out of the mixture upon standing. The particles in a suspension are far larger than those of a solution and thus gravity is able to pull them down out of the dispersion medium (water).
Why are suspensions used in medicine?
Substances can be chemically unstable, insoluble in water, distasteful etc. Suspensions are often used as a dosage form when the drug is insoluble in water and when use of solubilizing agents is not possible.
What is the viscosity of a suspending agent?
A range of viscosities of suspending agents is available with different molecular weights. In particular, aqueous 1% w/v MC 400 cP has many of the characteristics of an ideal vehicle:
What kind of molecule is a suspending agent?
Suspending agents that hindercoalescence may be either water soluble polymers, often called protective colloids, or finely divided insoluble inorganic compounds.
What are the suspending agents in nasal spray?
Suspending agents are also used in nasal spray formulations to reduce the rate of settling of suspended active ingredients. The most common suspending agents are aqueous biological polymers, including methylcellulose (MC), sodium carboxymethylcellulose (CMC), and hydroxypropylmethylcellulose (HPMC).
Why is MC used as a suspending agent?
In suspensions, MC can extend the contact time of therapeutic agents in the stomach and increases the time needed for settling due to its viscosity enhancing properties ( Dias and Duarte, 2013 ).